Shortly after announcing that Mansquito's nemesis would be called Angelo Codevilla, Dennis Miller rescinded the statement, saying that Codevilla would be better suited as a mentor to Mansquito, similar to the M character in the James Bond films.

Meanwhile, a nemesis for Mansquito has been developed - Arch Genome, an evil scientist who is "trying to blur the double helix between man and skeeter." No actor has been attached to the Arch Genome role as of yet.